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- PREVALENCE AND SIGNS - (redirected from - PREVALANCE -)

Page history last edited by Shamel Wellington 8 years ago


Beckwith-Wiedemann Syndrome: Prevalence  



Ten to fifteen percent of BWS is due to autosomal dominant inheritance pattern where a mutation occurs in one gene. Children born to a parent carrying 50% of the mutation has half a chance (50%) of inheriting the mutation (Gennatas, 2013). The incidence is higher in infants from in vitro fertilization (BWS, Cancer.net, 2013).


There is no rare prediction observed and the disease occurs equally in all races and both sexes. However, the frequency tends to be higher in female monozygotic twins versus male monozygotic twins (Weksberg, 2002).


This parenthetic disorder is estimated to occur in every 1 of 13,700 births worldwide. Weng, 1995 states that there is an 85% occurrence of BWS occurring sporadically but familial transmission occurs in approximately 15% of the cases. BWS has been observed in 33% of fetuses or live born infants from complications due to placental mesenchymal dysplasia during pregnancy. It was observed that 50% of these infants were born preterm with a long umbilical cord and a placenta that was two folds of the average normal weight for the gestational age (Weng, 1995).




Beckwith-Wiedemann Syndrome : Signs and Symptoms 



The  signs and symptoms of BWS vary among affected infants and children. They typically include omphalocele, umbilical hernia, macroglossia, visceromegaly, hypoglycemiaand renal abnormalities (Genetics Home Reference, 2008).




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