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Cancer cells have genome-wide aberrations at the epigenetic level, some include global hypomethylation, promoter specific hypermethylation, histone deacetylation, global-down-regulation of miRNAs, and up-regulation of epigenetic factors. These irregularities have a selective growth benefits such as causing tumors, out of control cell multiplying, and not being able to shut these processes down.
(Taby et al, 2010).
Epigenetic Tumor Markers
The earlier someone can find about abnormal growth the better their chances of survival are, but many of the methods used for prevention and techniques that are used for detection have their restrictions. With epigenetics this can become a fathomable way to prevent and diagnose cancer (Dumitrescu, 2012). Research in early stage breast cancer has unveiled some of these epigenetics changes in certain genes (P16INK4a, BRCA1, and BRCA2) that occurred via promoter hyper methylation. Similar research has occurred in other form as cancer as well. One study for lung cancer was able to detect hyper methylation in sputum years before the appearance of the illness occurred. The reasons for these changes can be encouraged from xenoestrogens, foliate, and multivitamins and detection of these changes may help in determining cancer susceptibility and early diagnosis
Utilizing abnormal DNA methylation that are on regions of DNA or more specific genes in a clinical environment come from its frequency, stability, and variability between patients. As mentioned earlier, DNA methylation is a stable and reproducible marker, because DNA is more resilient than RNA in regards to breaking down. Highly sensitive and/or quantitative methylation detection techniques are available, such as bisulfite pyrosequencing, methylation-specific polymerase chain reaction, or bisulfite treatment combined with high-throughput deep sequencing. In addition aberrant methylation of some gene promoters is more shared and simpler to detect than the presence of mutations (Taby et al
DNA is embedded in non-neoplastic cells or normal DNA molecules. Examples illustrating the potential use of biological epigenetic indicators in clinical location are explained in Table 1 (Taby et al).
Click on video for a brief overview on Epigenetics
can contribute to the developement of cancer
Video Link: http://www.youtube.com/watch?v=hVfQXi190nk
Image link:http://www.awaremed.com/cancer-can-be-prevented-cancer-can-regress-and-cancer-can-be-cured/
Comments (5)
djohn1@sgu.edu said
at 7:55 pm on Nov 25, 2013
Excellent job here!
Ilambert said
at 1:48 pm on Nov 28, 2013
Very informative. Good use of the video
Deirdre Greenidge said
at 7:21 pm on Nov 28, 2013
Very good!
Jeremy said
at 1:06 am on Nov 29, 2013
Great job
kmcdonal said
at 5:36 pm on Nov 29, 2013
On behalf of Group 5, we thank you for your encouraging remarks.
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