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group 5 epigenetic markers and cancer

Page history last edited by kmcdonal 10 years, 4 months ago

Back to Home page                                                                                                                                           Next to Future of Epigenetics

 

 

 

Cancer cells have genome-wide aberrations at the epigenetic level, some include global hypomethylation, promoter specific hypermethylation, histone deacetylation, global-down-regulation of miRNAs, and up-regulation of epigenetic factors. These irregularities have a selective  growth benefits such as causing tumors, out of control cell multiplying, and not being able to shut these processes down.

 (Taby et al, 2010).

 

Epigenetic Tumor Markers

 

The earlier someone can find about abnormal growth the better their chances of survival are, but many of the methods used for prevention and techniques that are used for detection have their restrictions. With epigenetics this can become a fathomable way to prevent and diagnose cancer (Dumitrescu, 2012).  Research in early stage breast cancer has unveiled some of these epigenetics changes in certain genes (P16INK4a, BRCA1, and BRCA2) that occurred via promoter hyper methylation.  Similar research has occurred in other form as cancer as well. One study for lung cancer was able to detect hyper methylation in sputum years before the appearance of the illness occurred.  The reasons for these changes can be encouraged from xenoestrogens, foliate, and multivitamins and detection of these changes may help in determining cancer susceptibility and early diagnosis 

Utilizing abnormal DNA methylation that are on regions of DNA or more specific genes in a clinical environment come from its frequency, stability, and variability between patients. As mentioned earlier, DNA methylation is a stable and reproducible marker, because DNA is more resilient than RNA  in regards to breaking down.  Highly sensitive and/or quantitative methylation detection techniques are available, such as bisulfite pyrosequencing, methylation-specific polymerase chain reaction, or bisulfite treatment combined with high-throughput deep sequencing. In addition aberrant methylation of some gene promoters is more shared and simpler to detect than the presence of mutations (Taby et al

DNA is embedded in non-neoplastic cells or normal DNA molecules. Examples illustrating the potential use of biological epigenetic indicators in clinical location are explained in Table 1 (Taby et al).

 

 

 

 

 

 

Click on video for a brief overview on Epigenetics

can contribute to the developement of cancer

Video Link: http://www.youtube.com/watch?v=hVfQXi190nk

 


 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Image link:http://www.awaremed.com/cancer-can-be-prevented-cancer-can-regress-and-cancer-can-be-cured/  

Comments (5)

djohn1@sgu.edu said

at 7:55 pm on Nov 25, 2013

Excellent job here!

Ilambert said

at 1:48 pm on Nov 28, 2013

Very informative. Good use of the video

Deirdre Greenidge said

at 7:21 pm on Nov 28, 2013

Very good!

Jeremy said

at 1:06 am on Nov 29, 2013

Great job

kmcdonal said

at 5:36 pm on Nov 29, 2013

On behalf of Group 5, we thank you for your encouraging remarks.

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